• Wegovy & Ozempic are both Semaglutide, which we sell under the name Slim. 

• Mounjaro is Tirzepatide, which we sell under the name Trim. 

• Reta is Retatrutide, which we sell under the name Reignite. 

Clinical data shows a clear hierarchy:

• Semaglutide (Sema): ~10–15% average weight loss

• Tirzepatide (Tirz): ~15–22% average weight loss

• Retatrutide (Reta): ~20–25%+ average weight loss (early trial data)

👉 Retatrutide currently shows the highest % weight loss, followed by Tirzepatide, then Semaglutide.

Keep in mind: 

• the results quoted above were from participants that followed the typical dosage escalation protocol. That is, every 4 weeks they increased dose until they reached the highest dose. If you do not also increase dose, you should not expect to achieve such high results. Some people prefer the low and slow approach, and keep their doses low (mainly to save money) which is fine, but please realise that this means your weightloss rate may also be slowed. 

• results vary based on dose, consistency, lifestyle, and individual response - so the “best” option can differ person to person.

• In Reta trials especially, very few participants saw consistent weightloss below 8mg/week

You should start on a dose no higher than 0.25mg/week to allow your body to get used to the effects of the medication. The typical dosing escalation pathway for Slim (semaglutide) is:

• 0.25mg/week - starting dose to minimise side effects. Unlikely to see weightloss at this dose. 

• 0.5mg/week

• 1mg/week

• 1.7mg/week

• 2.4mg/week

• (recently approved in the UK) 7.2mg/week

A dose of 1mg/week and higher is considered a therapeutic dose - that is, a dose where the medication should be inducing continued and sustained weightloss in most individuals. 

You should start on a dose no higher than 2.5mg/week to allow your body to get used to the effects of the medication. The typical dosing escalation pathway for Trim (tirzepatide) is:

• 2.5mg/week -starting dose to minimise side effects. May see little to no weightloss at this dose. 

• 5mg/week

• 7.5mg/week

• 10mg/week

• 12.5mg/week

• 15mg/week

Some people find the jump from 2.5mg to 5mg/week a bit of a challenge with side effects and have found better success going from 2.5mg > 3.75 >5mg over time instead. 

A dose of 5mg/week and higher is considered a therapeutic dose - that is, a dose where the medication should be inducing continued and sustained weightloss in most individuals. 

You should start on a dose no higher than 2mg/week to allow your body to get used to the effects of the medication. The typical dosing escalation pathway for Reignite (Retatrutide) is:

• 2mg/week

• 4mg/week

• 6mg/week

• 8mg/week

• 10mg/week

• 12mg/week

A dose of 8mg/week and higher is considered a therapeutic dose - that is, a dose where the medication should be inducing continued and sustained weightloss in most individuals. 

Read more about Reignite dosing on Page 8 of of the Detailed Reignite Guide. 

You should only increase your dose when your body is ready for it - not just because time has passed.

Here’s how to know:

✅ Stay at your current dose if:

• Your appetite and cravings well controlled

• You’re still losing weight steadily (a safe weight loss is 500g/week, when averaged over a 4 week period)

• Side effects are still quite strong (don't increase if you're still getting strong side effects, it will likely only get worse)

👉 If it’s working, there’s no rush to go up.

⬆️ Consider increasing your dose if:

• Hunger and cravings are coming back too strong for you to manage

• Weight loss has stalled for 4 weeks or more (a couple of weeks is not a stall, it's normal to have weeks where the scale doesn't move, and even some weeks you gain. Weightloss is never linear). 

• You feel like the effect has worn off between doses

• You’re tolerating your current dose without side effects
  
  

Timing matters

Most people increase every 4 weeks, but this isn’t a rule - it’s just a guide. This is because after 4 weeks at a continuous dose, the medication has reached a steady state. 

The key mindset

More isn’t always better. The goal is to find your lowest effective dose - the one that gives you results with the least side effects.

If you’re unsure, it’s always safest to hold your dose a bit longer rather than rushing up too quickly.

You’re not chasing the highest dose - you’re building something sustainable ✨

This is a really important piece most people don’t realise 

It’s not just about one dose - it builds over time

These medications don’t fully “kick in” from a single injection. They have a cumulative effect, meaning each dose adds to what’s already in your system.

Because they have a long half-life (around ~5–7 days), your body still has some medication from your previous dose when you take your next one.

👉 So week by week, levels gradually build and stabilise.

📈 What that means for you

• The full effect of a dose isn’t immediate - it can take 2–4 weeks to truly feel it

• Appetite suppression and weight loss often improve over time, even without increasing

• What feels “mild” in week 1 can feel much stronger by week 3–4
  
  

⚠️ Why increasing too quickly can backfire

If you increase your dose too soon, you’re not just increasing that week’s dose - you’re stacking on top of what’s already building in your body.

This can lead to:

• Sudden strong side effects (nausea, fatigue, etc.)

• Feeling over-suppressed (no appetite at all)

• Having to drop your dose back down

✅ The smarter approach

Give each dose time to fully settle and show its effect before deciding it’s “not enough.”

In simple terms:
👉 What you feel today isn’t just today’s dose, it’s the result of the last few weeks combined.

That’s why patience here = better results, fewer side effects, and a much smoother journey ✨

This is totally normal and honestly, the first month isn’t always where the magic happens. We know you want to see 'something' happening for all the money you've spent and pain you have endured (needles, ouch!), but it's not about quick results with these medications. 

Your body is still adjusting

In the first few weeks, your body is getting used to the medication. Levels are still building (it’s cumulative, see earlier questions), and most people are on a low starter dose, which is designed for tolerance - not maximum results.

Weight loss often lags behind appetite changes

You might notice:

• Less hunger

• Smaller portions

• Fewer cravings

But the scale doesn’t always move straight away - your body can take a few weeks to respond.

Other factors at play

Early on, things like fluid retention, hormones, sleep, stress, and diet changes can mask fat loss on the scale. This is why it's so important to have more measures of success than just your scales. 

When results usually kick in

Most people start to see more noticeable weight loss around weeks 4–8 (Slim 7 Trim) and Weeks 9-12 (Reignite), especially as:

• The medication builds in your system

• Doses are gradually increased (if needed)

• Habits start to align with reduced appetite
  
  

What to focus on right now

We have seen some customers quit and give up after just 4 weeks, declaring the medication 'isn't working for them'. These medications do work for 98% of people that follow consistent, sustained use. But we would suggest you trust the process and focus on:

• Consistency with dosing

• Listening to your hunger cues

• Keeping meals balanced (protein helps a lot) and in a calorie deficit 

• Ensuring high enough water intake (3L a day is the goal)

• Introducing gentle movement 

• Reviewing the clinical trial data for your medication, to see if your expectations align with results the medication has been shown to achieve. 

👉 You’re not “failing”-  you’re in the setup phase.

Stick with it. This is where your body is laying the groundwork for results that actually last.