Yes, it's quite normal - hunger is one of those signals that has many inputs and can be influenced by:

• hormones (monthly fluctuations for women), 

• stress (causes more grehlin hormone to be released), 

• how much exercise you do (more can sometimes make you feel hungrier as your body attempts to replace calories burned), 

• what your food choices are (high protein will keep your fuller for longer), 

• how much water you've been drinking (dehydration can be felt as hunger by some people), and 

• how long you have been at the same dose of the medication. If you've been at the same dose for a while, it may just be the effectiveness is wearing off over time. Here's a section on the Glow Getter Hub that talks about the last point. 

Some people have found hunger can just randomly ramp up one week and then go back to normal the next (and they couldn't figure out why). Give it a few weeks before you decide to increase the dose - try not to make a dosing decision based only on 1 week. 

While the medication can dampen hunger, don't forget that it can also reduce your portions you eat at a meal. So you might still get really hungry to eat lunch, but then when you start eating, you might be satisfied with a smaller portion than a person not taking Trim. Only you will know how you 'usually' feel on the medication and what is normal for you. 

Unfortunately this is the most common side effect of Glow Up (GHKCU) and most people experience it. The Glow Up 100 vials are most likely to cause stinging, as they are twice as concentrated as the Glow up 50 vials. It’s caused by the copper component and is completely normal (not a quality issue). Some people feel it more than others, and sensitivity can even change over time. Some people build tolerance to it, and for others their body actually becomes more sensitive to it over time. 

How to reduce the sting:

• Most likely to work: dilute it more (add extra bacteriostatic water). The best way to do this is to draw up your usual dose into the syringe, and then draw up additional bac water into the same syringe, like this video demonstrates. 

• Let it reach room temperature before injecting

• Inject the liquid slowly

• Use a longer needle (e.g. 12mm vs 6–8mm) as this will penetrate deeper into your fatty tissue, and not be too close to skin surface

• Try different injection sites (upper glutes/love handles are some favourites mentioned by our community)

• Rotate the injection sites each day (even if only from left to right)

• ice the area first, or apply numbing cream if you have it on hand

• ensure you pinch enough fat. If you get it into the muscle it can be very painful

• apply gentle pressure to the area after (don't rub it) as this disperses the liquid

• you can take an anti-histamine an hour beforehand to reduce the histamine reaction your body produces

• split your dose into 2, and take some morning and night, that way you're injecting less each time, but still getting the same daily dose

Even after trying all of this, there are about 1% of people that find it's still too uncomfortable and not worth the pain for the benefits you receive (fair enough!). If this is you, I'm sorry that we don't offer refunds - it's not a product issue, it's just one of those things that it wasn't suitable for you. 

If you're switching from another weightloss medication to Reignite (Reta), and finding the results of the first few weeks underwhelming, that's not usual - let's check in with what is normal. 

Reignite (retatrutide) doesn’t always feel instant - and that’s because it works differently to Trim (tirzepatide/ Mounjaro).

While Trim targets GLP-1 and GIP receptors, retatrutide adds a third pathway (glucagon), which shifts it from just appetite control into also influencing energy expenditure.

That broader mechanism can take time for your body to adapt to, so the effects often build more gradually rather than hitting all at once. If you’re switching from Trim, this is even more noticeable - your body is already familiar with GLP-1 activity, so you may not feel much at the lower doses of Reignite.

Many people only start to notice stronger appetite suppression and momentum as doses increase. As we discuss in our Reignite guide, the therapeutic dose for Retatrutide is 8mg/week and higher - that is the dose at which most people in clinical trials saw sustained, continued weightloss. 

If you're only going by the number on the scales, you'll probably be underwhelmed early on. Stick with it, monitor your calories, increase the doses when it feels right and also take body measurements. A lot of people find that their body shape is changing even if the scales stay the same. 

Bottom line: it’s not that it’s “not working” - it’s that it’s working differently, and the real results come as you titrate up and stay consistent.